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Pump 'enables fermentation-powered drug-delivery patches'

Researchers have created a new type of miniature pump activated by body heat that could be used in drug-delivery patches powered by fermentation.

The micropump is said to contain Baker’s yeast and sugar in a small chamber. When water is added and the patch is placed on the skin, the body heat and the added water causes the yeast and sugar to ferment, generating a small amount of carbon-dioxide (CO2) gas.

The gas pushes against a membrane and has been shown to continually pump for several hours, said Babak Ziaie, a Purdue University professor of electrical and computer engineering and biomedical engineering.

According to a statement, such miniature pumps could make possible drug-delivery patches that use arrays of microneedles to deliver a wider range of medications than now possible with conventional patches.

Unlike many other micropumps under development or in commercial use, the new technology requires no batteries, said Ziaie, who is working with doctoral student Manuel Ochoa.

‘This just needs yeast, sugar, water and your own body heat,’ Ziaie said.

The robustness of yeast allows for long shelf life, and the design is ideal for mass production, Ochoa added.

‘It would be easy to fabricate because it’s just a few layers of polymers sandwiched together and bonded.’

Findings were detailed in a research paper published online in August in the journal Lab on a Chip. The paper was written by Ochoa and Ziaie, and the research is based at Purdue’s Birck Nanotechnology Center in the university’s Discovery Park.

The micro-organism-powered thermopneumatic pump is made out of layers of polydimethylsiloxane, which is used commercially for diaphragms in pumps, and the prototype is 1.5cm.

Current transdermal patches are limited to delivering drugs that, like nicotine, are made of small hydrophobic molecules that can be absorbed through the skin, Ziaie said.

‘Many drugs, including those for treating cancer and auto-immune disorders cannot be delivered with patches because they are large molecules that won’t go through the skin,’ he said. ‘Although transdermal drug delivery via microneedle arrays has long been identified as a viable and promising method for delivering large hydrophilic molecules across the skin, a suitable pump has been hard to develop.’

Patches that use arrays of tiny microneedles could deliver a multitude of drugs, and the needles do not cause pain because they barely penetrate the skin, Ziaie said. The patches require a pump to push the drugs through the narrow needles, which have a diameter of about 20 microns.

Most pumps proposed for drug-delivery applications rely on an on-board power source, which is said to be bulky, costly and requires complex power-management circuits to conserve battery life.

‘Our approach is much simpler,’ Ziaie said. ‘It could be a disposable transdermal pump. You just inject water into the patch and place it on your skin. After it’s used up, you would throw it away.’

Researchers have filed an application for a provisional patent on the device.

This diagram shows a new type of miniature pump activated by body heat that could be used in drug-delivery patches powered by fermentation. The micropump works by harnessing the pressure generated by fermenting yeast. Such drug-delivery patches might use

Source: Purdue University image/Manuel Ochoa

This diagram shows a new type of miniature pump activated by body heat that could be used in drug-delivery patches powered by fermentation. The micropump works by harnessing the pressure generated by fermenting yeast. Such drug-delivery patches might use arrays of microneedles to deliver a wider range of medications than now possible with conventional patches


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