3D printed guide helps repair of damaged nerves

Scientists at Sheffield University of have succeeded in using a 3D printed guide to help damaged nerves repair themselves.

The team used the device to repair nerve damage in animal models and say the method could help treat many types of traumatic injury.

The University said the device – a nerve guidance conduit (NGC) – is a framework of tiny tubes that guide the damaged nerve ends towards each other so that they can repair naturally.

Patients with nerve injuries can suffer complete loss of sensation in the damaged area and current methods of repairing nerve damage require surgery to suture or graft the nerve endings, a practice which often yields imperfect results.

According to the University, some NGCs are currently used in surgery but they can only be made using a limited range of materials and designs, making them suitable for a limited range of injuries.

The technique, developed in Sheffield’s Faculty of Engineering, uses Computer Aided Design (CAD) to design the devices, which are then fabricated using laser direct writing, a form of 3D printing. The advantage of this is that it can be adapted for any type of nerve damage or even tailored to an individual patient.

Researchers used the 3D printed guides to repair nerve injuries using a novel mouse model developed in Sheffield’s Faculty of Medicine, Dentistry and Health to measure nerve regrowth. They were reportedly able to demonstrate successful repair over an injury gap of 3mm, in a 21-day period.

In a statement, John Haycock, Professor of Bioengineering at Sheffield said: ‘The advantage of 3D printing is that NGCs can be made to the precise shapes required by clinicians.

‘We’ve shown that this works in animal models, so the next step is to take this technique towards the clinic.’

The Sheffield team used polyethylene glycol, which is already cleared for clinical use and is also suitable for use in 3D printing.

‘Further work is already underway to investigate device manufacture using biodegradable materials, and also making devices that can work across larger injuries,’ said Dr Frederik Claeyssens, senior Lecturer in Biomaterials at Sheffield.

‘Now we need to confirm that the devices work over larger gaps and address the regulatory requirements,’ said Fiona Boissonade, Professor of Neuroscience at Sheffield.

The research, published in Biomaterials, was funded by the Engineering and Physical Sciences Research Council and the Medical Research Council.