Anti-cancer agent

Researchers at Warwick University are developing compounds of a precious metal as an anti-cancer agent.


Researchers at Warwick University are hoping to use compounds of a precious metal, which has never before been used in a clinical setting, as an anti-cancer agent.


The metal, osmium, is closely related to platinum, which is widely used to treat cancers in the form of the drug cisplatin.


Based in the Department of Chemistry at the university, the researchers are working closely with Warwick Ventures, the university’s technology transfer office, to seek partners to help develop the potential of osmium through more extensive biological tests.


Prof Peter Sadler, of the Department of Chemistry, said: ‘Although cisplatin has been proven to be a very successful treatment, it is not useful for all kinds of cancer.


It is also quite a toxic therapy, which can produce side effects and, from a clinical point of view, cells can also become resistant to platinum.’


Osmium, with its special chemical properties, offers a new potential solution to an unmet clinical need.


It has shown huge promise in treating several different types of cancer cell, including ovarian and colon cancers developed and tested in the laboratory.


The metal also has another advantage in that it is a much cheaper alternative to platinum.


Sadler, along with post-graduate researcher, Sabine van Rijt, is working to develop new compounds using osmium, which he hopes will lead to the development of drugs that could be used in combination therapies alongside existing drugs such as cisplatin.


Van Rijt said: ‘The compounds we have been developing are very promising,


‘We’re building a picture of how different compounds might interact with DNA in cancer cells.


‘By making changes to the coating, or ligand, on the metal, we can also affect not just how it interacts, but the rate of interaction.


‘During this design process we can also make changes that can control the activity of the compound.’


She added: ‘Another advantage is that these compounds are not cross-resistant with platinum.


‘They kill the cancerous cells in a different way, so they could be used alongside platinum in combination therapies.’