Prof Harwood from the
The technology works by forming chains with a nitrogen molecule at one end (the nitrogen terminus) and an acid molecule at the other (the acid terminus). This methodology opens the door to a new type of peptide synthesis in which multiple peptide chains can be brought together to make a long chain without loss of yield of the pure form. It also enables much more efficient manufacture of circular peptide chains (cyclic peptides).
The new method should increase yield, efficiency and flexibility in peptide manufacturing, and will help to produce new peptide-based pharmaceutical drugs.
Prof Harwood said: ‘So far we have proof of concept in solution but, to be of real interest, we need to demonstrate its effectiveness in the conditions that would be used in a manufacturing environment.’