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Chemical imaging specialists at Malvern Instruments have published an application note.

The note demonstrates that, by reverse engineering pharmaceutical tablets using data from the Synirgi near-infrared chemical-imaging (NIR-CI) system, they could determine extensive and detailed information about the formulations and processing techniques used to create each dosage.

This is said to have valuable applications in troubleshooting product failures.

The application note, entitled ‘NIR chemical imaging for tablet deconstruction: A case study for solid dosage forms’, can be downloaded from the Malvern knowledge database on the website.

While high-performance liquid chromatography (HPLC) can provide basic information about a product makeup, the application of NIR-CI adds novel information relating to its manufacture.

Using Malvern Isys chemical-imaging analysis software to evaluate the size, shape and proximity of chemical components, the Synirgi global imaging approach provides a visual representation of a product composition and engineered structure.

Synirgi delivers robust automated sampling capabilities that deliver rapid data acquisition, as well as advanced data analysis via an easy-to-use interface.

The NIR-CI technique demonstrated in the Malvern application note takes advantage of Synirgi hardware and Isys software advanced features.

This type of reverse engineering has demonstrated the ability to help understand product failures and can primarily be used for troubleshooting.

The wealth of chemical and physical information in a chemical image provides a fingerprint of the tablet production properties and, ultimately, its performance.

It is suitable for pharmaceutical dosage analysis and enables refined quality control.

Malvern Instruments

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