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Lipid Emulsions for Intravenous Application Particle Size by DLS - .PDF file.

Dynamic Light Scattering

Intravenous infusions are administered directly into the bloodstream, and thus do not pass through the protective filters of the digestive system before being circulated through somewhat vulnerable areas, such as the heart and lungs. A common risk from intravenous infusions is contamination by particles that are not visible to the eye.

Contamination can have many sources, including unwanted chemical reactions of the drug, incompatibility with other drugs or glass ware, rubber particles from the product’s container, or precipitation of the drug. Precipitation is caused by low or decreased drug solubility, which can arise through too-high drug concentration, or through the solvent’s pH or ionic strength. If the drug is more lipophilic and hard to dissolve or disperse in water, it is more likely that particles may precipitate.

These unwanted particles can lead to severe problems such as heart attacks, phlebitis, thrombosis or embolisms in the lung. Particles can arise during production or storage, and can be caused by glass ware, dust, precipitation of the drug, rubber or any other material in contact with the product.

In addition to the health risks, there are also financial consequences that should be considered. Contamination by particles can lead to extended hospital stays and treatments, which generally carry high costs.

Therefore, for quality-control purposes, it is important to check for such unwanted particles.

Dynamic light scattering is a fast and accurate way to analyse the particle size and particle-size distribution, even with small sample amounts.

In an application report from Anton Paar, an experiment is carried out to show how DLS can be used to measure particle size and prevent contaminations.

Click on the link above to download the Application Report and to learn about the results of their experiment.

Anton Paar Ltd

Anton Paar develops, produces and distributes highly accurate laboratory instruments and process measuring systems, and provides custom-tailored automation and robotic solutions.

Anton Paar develops, produces and distributes highly accurate laboratory instruments and process measuring systems, and provides custom-tailored automation and robotic solutions.

It is the world leader in the measurement of density, concentration and CO2 and in the field of Rheometry. Other areas of specialty are: Viscometry, Polarimetry, Refractometry, Microwave Sample Preparation & Synthesis, Chemical and Mechanical Surface and Nanostructure Analysis.

With over 2200 employees at the headquarters in Graz (Austria) and the 25 sales subsidiaries worldwide, Anton Paar ensure that their products live up to their excellent reputation. The core competence of the company – high-precision production – and close contact to the scientific community form the basis for the quality of Anton Paar’s instruments.

A strong sales network in more than 110 countries guarantees customers rapid support and answers to their application and service queries.

Innovation is the basis for progress and every year Anton Paar invests more than 20 percent of the annual turnover in R&D.

Anton Paar Limited, a subsidiary of Anton Paar GmbH, provides sales, application support and service to users across the UK and Ireland.

With an office in St Albans (UK) and Dublin (Ireland) and a team of over 30 dedicated employees, Anton Paar Limited aims to provide first-class service at every stage in the customer relationship, ensuring our products live up to their excellent reputation.

Anton Paar Ltd
Unit F, The Courtyard
St Albans
AL4 0LA
UK

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