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Microcrystalline cellulose is a very versatile substance used in the lab. As the name implies, microcrystalline cellulose is basically cellulose and is typically derived from high-quality wood pulp. It is a commonly used excipient in the pharmaceutical industry and has revolutionised tableting because of its unique compressibility and carrying capacity. It compacts well under minimum compression pressures, has high binding capability and creates tablets that are extremely hard yet disintegrate rapidly. Other advantages include low friability, inherent lubricity and the highest dilution potential of all binders.

The chemical composition and physical structure of microcrystalline cellulose depend significantly on the characteristics of the used raw material and the manufacturing conditions. As a result, several types of microcrystalline cellulose are available in the market with different physicochemical and thermal properties. These differences can affect the compactibility and compressibility and subsequently the application of the material.

As a consequence their characterisation must undergo extensive tests for identity, purity, degree of crystallinity, molecular structure and molecular weight (or intrinsic viscosity) to guarantee the behaviour of the excipient according to its application.

This application report shows how to measure the intrinsic viscosity of microcrystalline cellulose with the combination DMA 4500 M Density Meter and Lovis 2000 ME Microviscometer Module. The measurement is performed according to ASTM Test Method D1795, the sample preparation according to USP 36 – NF 31, Monograph: Microcrystalline Cellulose.

Anton Paar Ltd

Anton Paar develops, produces and distributes highly accurate laboratory instruments and process measuring systems, and provides custom-tailored automation and robotic solutions.

Anton Paar develops, produces and distributes highly accurate laboratory instruments and process measuring systems, and provides custom-tailored automation and robotic solutions.

It is the world leader in the measurement of density, concentration and CO2 and in the field of Rheometry. Other areas of specialty are: Viscometry, Polarimetry, Refractometry, Microwave Sample Preparation & Synthesis, Chemical and Mechanical Surface and Nanostructure Analysis.

With over 2200 employees at the headquarters in Graz (Austria) and the 25 sales subsidiaries worldwide, Anton Paar ensure that their products live up to their excellent reputation. The core competence of the company – high-precision production – and close contact to the scientific community form the basis for the quality of Anton Paar’s instruments.

A strong sales network in more than 110 countries guarantees customers rapid support and answers to their application and service queries.

Innovation is the basis for progress and every year Anton Paar invests more than 20 percent of the annual turnover in R&D.

Anton Paar Limited, a subsidiary of Anton Paar GmbH, provides sales, application support and service to users across the UK and Ireland.

With an office in St Albans (UK) and Dublin (Ireland) and a team of over 30 dedicated employees, Anton Paar Limited aims to provide first-class service at every stage in the customer relationship, ensuring our products live up to their excellent reputation.

Anton Paar Ltd
Unit F, The Courtyard
St Albans
AL4 0LA
UK

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