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Dynamic light scattering of liposomes - .PDF file.

liposomes

Liposomes play an important role in medical and pharmaceutical science as drug carriers, especially for cancer therapy due to their natural ability to target cancer cells.

The endothelial walls of all healthy human blood vessels are encapsulated by endothelial cells that are bound together by tight junctions. These junctions stop any large particles in the blood from leaking out of the vessel. Tumour vessels, in contrast, do not contain the same level of seal between cells and are characteristically ‘leaky’, so liposomes of <400nm can enter tumour sites from the blood. Doxorubicin, camptothecin and daunorubicin are anti-cancer drugs that are currently being produced in liposome-delivery systems. Thus, for cancer treatment uses, it is essential to be able to measure the size of such liposomes, and to know whether they are stable in solution over time.

To this purpose, an experiment has been carried out using the Litesizer 500 from Anton Paar to determine the size distribution of liposomes in solution by using dynamic light scattering (DLS). Furthermore, the size of the liposomes was monitored as a function of time, as well as temperature and buffer concentration.

In an experiment carried out using an MCR 302 rheometer from Anton Paar rheometer and its accessories, a commercial soluble coffee powder was mixed in different concentrations with distilled water.

Click on the link above to download the two-page Application Report with all the details and interesting results of this experiment.

Anton Paar Ltd

Anton Paar develops, produces and distributes highly accurate laboratory instruments and process measuring systems, and provides custom-tailored automation and robotic solutions.

Anton Paar develops, produces and distributes highly accurate laboratory instruments and process measuring systems, and provides custom-tailored automation and robotic solutions.

It is the world leader in the measurement of density, concentration and CO2 and in the field of Rheometry. Other areas of specialty are: Viscometry, Polarimetry, Refractometry, Microwave Sample Preparation & Synthesis, Chemical and Mechanical Surface and Nanostructure Analysis.

With over 2200 employees at the headquarters in Graz (Austria) and the 25 sales subsidiaries worldwide, Anton Paar ensure that their products live up to their excellent reputation. The core competence of the company – high-precision production – and close contact to the scientific community form the basis for the quality of Anton Paar’s instruments.

A strong sales network in more than 110 countries guarantees customers rapid support and answers to their application and service queries.

Innovation is the basis for progress and every year Anton Paar invests more than 20 percent of the annual turnover in R&D.

Anton Paar Limited, a subsidiary of Anton Paar GmbH, provides sales, application support and service to users across the UK and Ireland.

With an office in St Albans (UK) and Dublin (Ireland) and a team of over 30 dedicated employees, Anton Paar Limited aims to provide first-class service at every stage in the customer relationship, ensuring our products live up to their excellent reputation.

Anton Paar Ltd
Unit F, The Courtyard
St Albans
AL4 0LA
UK

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