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Wyatt Technology has announced that its instruments have been used in a study that has furthered scientific understanding of immunity to viral diseases such as the common cold and gastroenteritis.

The research, carried out by the United Kingdom’s Medical Research Council Laboratory of Molecular Biology demonstrates the ability of tripartite motif-containing 21 (TRIM21) to neutralise viral infection.

The company’s multi-angle light scattering (MALS) detectors were used to monitor the interaction between TRIM21 and immunoglobulin G (IgG).

Viruses such as the common cold, AIDS and some forms of cancer are among the hardest diseases to treat and are adept at avoiding recognition by changing their molecular patterns.

Antibodies were originally thought to only offer extracellular protection and were helpless against the virus once it had entered the cytosol of a cell.

However, the new study shows that antibodies remain attached to viruses after cell infection and provide effective anti-viral immunity.

The Wyatt Heleos II instrument coupled to the Optilab Rex online refractive index detector were used to identify the positive interaction between a ctyosolic IgG receptor, Trim21 and IgG.

Scientists discovered that TRIM21 binds to antibodies with a higher affinity than any other IgG receptor in the human body and once activated begins to rapidly degrade virions in the cytosol, neutralising the infection.

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