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Intertronics has developed a mixing process for engineering compounds using the Thinky ARV-310 and Thinky ARV-5000 industrial non-contact planetary mixers.

In particular these machines are suitable for creating nano-particle suspensions of medical compounds more reliably and quicker than traditional methods, according to Intertronics.

This can often overcome problems of dilution where materials have negligible water solubility and enable mixing, dispersal and degassing in amounts as small as 0.5ml, up to large, laboratory level quantities.

The new process involves use of a Thinky mixer with zirconia balls, which can pulverise poorly water-soluble compounds such as medical drug doses using the 2,000rpm planetary technology.

In addition, use of the ARV vacuum mixer enables complete elimination of all air bubbles.

Commonly, a pestle and mortar are used for oral dosage formulations.

While this method is generally accepted and effective, this manual hand process is tedious and can lack repeatability or consistency.

The technique introduced by Intertrnoics is called NH-Step.

The company said that the NH-Step makes the mixing process easy, fast, improves physiochemical properties and can be applied to many oral suspensions.

For example, with an initial particle size of 18 micron, utilising the NH-Step process the particle distribution was reduced to two microns after only three minutes with the Thinky ARE-250.

The Thinky ARV-310 and Thinky ARV-5000 have the ability to process under vacuum, or under normal pressure, or even automatically switching into vacuum mode from non-vacuum state during the process.

It is possible to set the desired vacuum level for different types of ingredients.

These mixers are suitable for high-viscosity materials and materials for which a high degree of de-aeration is required.

They can eliminate micron-sized bubbles, without the danger of foaming and messy spillage.

Intertronics

INTERTRONICS supplies a comprehensive range of bonding and protective materials – together with the associated consumables and equipment – to customers in high technology, high performance assembly industries – including electronics, medical device, plastics, optical, automotive, energy, defence and aerospace.

INTERTRONICS supplies a comprehensive range of bonding and protective materials – together with the associated consumables and equipment – to customers in high technology, high performance assembly industries – including electronics, medical device, plastics, optical, automotive, energy, defence and aerospace. The company supplies over 3,000 regular customers, including multinational manufacturing giants, production facilities, specialist design and development businesses, universities, training organisations and government establishments.

adhere is INTERTRONICS’ brand which encompasses its bonding, coating, sealing, encapsulating, potting, masking and gasketing materials, together with the most appropriate equipment and accessories for dispensing and curing them.

Because adhere brings together this proven range of integrated products from selected and trusted partners, INTERTRONICS’ customers have the confidence that everything will work together efficiently and cost-effectively, underpinned by the company’s experience and expert advice.

This advice is an essential element of the programme, and it ensures that customers benefit from the optimal material and process choice for the manufacture, assembly or repair of their products … safeguarding and enhancing performance and integrity and in turn, profitability and reputation.

Also key to customer success and satisfaction are the provision of process implementation and training, ongoing expert technical support and the assurance of highly competent supply chain management.

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