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Liquid analysis Mixing and blending

White paper: Porvair Sciences focuses on improving sensitivity in microplate assays

By Porvair Sciences on 20th June 201315th December 2015

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‘Determination of well-to-well crosstalk in microplates used for luminescence measurements’ - .PDF file.

The use of luminescence assays and reagents in drug discovery has increased significantly over the past 10 years due to a combination of ease of use, very high specificity of assays and good sensitivity at low levels of screened compounds. Modern photometric instruments are able to accurately count very low levels of photon emissions from luminescence substrates and this has led to an increasing focus on the optical cross talk inherent in the design of SBS/ANSI standard microplates and the signal-to-noise ratio that can be experimentally obtained. This short paper compares the observable optical cross talk in three different manufacturers’ micro-well plates and finds that the use of a black supporting matrix can significantly improve sensitivity in microplate assays.

Click on the link above to download this white paper.

Porvair Sciences

Visit our website 01372 824290

Porvair Sciences Ltd has specialised in the manufacture of microplates and microplate equipment in the UK since 1992. Via our global distributor network, we serve Life Sciences, Biotechnology, R&D and Molecular Biology with microplate solutions for all applications, from sample preparation to high throughput screening. Our range includes assay plates, filter plates, SPE 96-well plates, vacuum manifolds & SPE cartridges together with deep well storage plates and seals. All our polypropylene products are guaranteed free of extractables & leachates which could contaminate stored compounds. Our range also includes heat sealers and dry-down stations.

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