A promising ultrasound treatment to reverse the effects of Alzheimer’s is on the road to clinical trials in Brisbane, Australia.
Developed by researchers at the University of Queensland (UQ), the technology first came to prominence in 2015. In the original trials, ultrasound was used to remove amyloid beta (Aβ) from mouse brains. Aβ is the main component of the amyloid plaques found in the brains of Alzheimer’s patients. Clearing it from mouse brains was found to restore memory and counteract the disease’s degenerative impact. Since then, the technique has also been successfully trialled on higher level mammals and a phase 1 safety trial on a small number of human patients is now due to take place in late 2019.
“The ultrasound waves oscillate tremendously quickly, activating microglial cells that digest and remove the amyloid plaques that destroy brain synapses,” said UQ’s Professor Jurgen Gotz, chairman of the Clem Jones Centre for Ageing Dementia Research.
“The word ‘breakthrough’ is often misused, but in this case I think this really does fundamentally change our understanding of how to treat this disease, and I foresee a great future for this approach.”
The ultrasound technique allows the blood-brain barrier to break down temporarily, allowing Aβ plaques to be flushed from the brain by the microglial cells. The non-invasive method requires no drugs, which means the treatment has the potential to be highly accessible if it does make it to market.
“The technology temporarily opens the blood-brain-barrier to remove toxic plaques from the brain and has successfully reversed Alzheimer’s symptoms and restored memory function in animal models,” said Professor Pankaj Sah, director of UQ’s Queensland Brain Institute (QBI).
“The human safety trials late next year are the next step, representing an investment in research that is already underway.”
Australia’s health minister has just announced Aus$10m in funding to advance the treatment. This, alongside significant philanthropic donations, has brought the project close to its Aus$30m target to commence clinical trials. Without a major breakthrough – whether via a technique such as this or the discovery of a new drug – the incidence of Alzheimer’s in the global population is set to rise dramatically over the coming years. The 2018 World Alzheimer Report estimated that the annual societal cost of the disease is already $1 trillion, and this will soar in tandem with the increasing prevalence.
“With an ageing population placing an increasing burden on the health system, an important factor is cost, and other potential drug treatments using antibodies will be expensive,” Professor Gotz said.
“In contrast, this method uses relatively inexpensive ultrasound and microbubble technology which is non-invasive and appears highly effective.”
Wow.
For such an important piece of research, why aren’t billions being spent to get it to market ASAP?
There have been many drugs developed over the last 2 decades which have shown to reduce the burden of amyloid beta from the brains of Alzheimer patients but fail on Phase III tests because they show no clinical benefit. There isn’t a strong correlation between the burden of amyloid beta in the brain and the severity of the symptoms. As far as I know the closest correlation between burden and severity comes from the accumulation of the Tau protein. There are very few companies investigating the clearance of Tau protein from the brain, so that is where I would put money in.
Interesting at the end of the video where it is stated that ultrasound alone has been found to disperse the tau protein clumping, Although I suppose the injection of micro bubbles has a scattering effect on the tau tangles, which would be difficult to achieve using ultrasound.
I wonder if this could also be applied to Lewy body aggregation in Parkinson’s?
I’ve read that it’s the immune system, let in from the blood, that does the job of clearing the plaques.
How do you found out how to participate in the trials? Do you have to be a citizen of Australia to be eligible?
As an ex researcher, although not medical, I often find the conservative academic nature of medical research irritating. I can understand that the elderly brain may have problems that a younger sufferer may not have, and obviously care must be taken. The scientific attitude is all very well, but surely the work done on this possible treatment should be being carried out in as many different places as possible throughout the world as close to now as can be.
Obviously this is a treatment for an already existing disease and does not deal with the root cause. Although there are sometimes simple things that could be done in order to prevent deterioration of brain function, one of which is a daily capsule of turmeric. I have found that this simple chemical has improved my memory and more physical problems considerably. For example I am 79 and for 74 0f those years have suffered from chronic catarrh. Which I can safely claim was cured by the turmeric – no other treatment worked. Is any work being done on brain deterioration using this?