Monitoring and treatment of eye diseases that could cause blindness may become a lot easier with a new imaging system that takes high-quality colour photographs of the whole retina.
The TEFI (Topical Endoscopic Fundal Imaging) system uses an endoscope with illumination and observation channels that are connected to a digital camera.
Using such a system, Prof Andrew Dick, David Copland and a team from Bristol University’s Academic Unit of Ophthalmology, monitored changes in mice retina over time, without distress to the animals or the need for anesthesia.
They focused on a condition in mice similar to human posterior uveitis, an inflammation that affects the back of the eye and that can be difficult to monitor using existing techniques.
TEFI allowed the researchers to see changes to the eye that were previously undetectable.
Prof Dick said: ‘Combined TEFI and histological methods enable the observation of clinical features and severity of disease, but information regarding the dynamics, phenotype, function and quantity of cellular traffic through the eye is only provided through detailed analysis of cell populations present in the eye at various stages of disease progression.’