AI detects abnormalities that cause epileptic seizures

The Multicentre Epilepsy Lesion Detection project (MELD) used over 1,000 patient MRI scans from 22 global epilepsy centres to develop the algorithm, which provides reports of where abnormalities are in cases of drug-resistant focal cortical dysplasia (FCD), which is a leading cause of epilepsy. The team’s findings are published in Brain.

FCDs are areas of the brain that have developed abnormally and often cause drug-resistant epilepsy. It is typically treated with surgery but identifying the lesions from an MRI scan is an ongoing challenge for clinicians as FCDs can look normal.

In a statement, co-senior author, Dr Sophie Adler, UCL Great Ormond Street Institute of Child Health, said: “We hope that this technology will help to identify epilepsy-causing abnormalities that are currently being missed. Ultimately it could enable more people with epilepsy to have potentially curative brain surgery.”

To develop the algorithm, the team quantified cortical features from the MRI scans, such as how thick or folded the cortex/brain surface was and used around 300,000 locations across the brain.

Researchers then trained the algorithm on examples labelled by expert radiologists as either being a healthy brain or having FCD – dependant on their patterns and features.

The findings found that overall, the algorithm was able to detect the FCD in 67 per cent of cases in the cohort of 538 participants.

Previously, 178 of the participants had been considered MRI negative, which means that radiologists had been unable to find the abnormality but the MELD algorithm identified the FCD in 63 per cent of these cases. This is particularly important: if doctors can find the abnormality in the brain scan then surgery to remove it can provide a cure.

Co-first author, Mathilde Ripart, UCL Great Ormond Street Institute of Child Health, said: “We put an emphasis on creating an AI algorithm that was interpretable and could help doctors make decisions. Showing doctors how the MELD algorithm made its predictions was an essential part of that process.”

Co-senior author, Dr Konrad Wagstyl, UCL Queen Square Institute of Neurology, added: "This algorithm could help to find more of these hidden lesions in children and adults with epilepsy, and enable more patients with epilepsy to be considered for brain surgery that could cure the epilepsy and improve their cognitive development. Roughly 440 children per year could benefit from epilepsy surgery in England."

In the UK some 600,000 people are affected by epilepsy. Drugs treatments are available for the majority of people with epilepsy, but 20-30 per cent do not respond to medications.

In children who have had surgery to control their epilepsy, FCD is the most common cause, and in adults it is the third most common cause. Additionally, of patients who have epilepsy that have an abnormality in the brain that cannot be found on MRI scans, FCD is the most common cause.

Co-first author, Dr. Hannah Spitzer, Helmholtz Munich, said: “Our algorithm automatically learns to detect lesions from thousands of MRI scans of patients. It can reliably detect lesions of different types, shapes and sizes, and even many of those lesions that were previously missed by radiologists.”

This study on FCD detection used the largest MRI cohort of FCDs to date, so can detect all types of FCD. According to UCL, the MELD FCD classifier tool can be run on any patient with a suspicion of having an FCD who is over the age of 3 years and has an MRI scan.