Cyber sniffer predicts radiotherapy side-effects

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Researchers have completed a study that may lead to clinicians being able to more accurately predict which patients will suffer from the side effects of radiotherapy.

Gastrointestinal side effects are said to be commonplace in radiotherapy patients and can occasionally be severe, yet there is no existing means of predicting which patients will suffer from them.

The results of the pilot study, published in the journal Sensors, outline how the use of an electronic nose and a newer technology, FAIMS (Field Asymmetric Ion Mobility Spectrometry) might help identify those at higher risk.

Warwick Medical School, working in collaboration with the School of Engineering and The Royal Marsden NHS Foundation Trust, led by Dr J Andreyev, carried out a pilot study to look into the relationship between levels of toxicity in the gut and the likelihood of experiencing side effects.

‘In the simplest terms, we believe that patterns in toxicity levels arise from differences in a patient’s gut microflora,’ said Dr Ramesh Arasaradnam, of Warwick Medical School and gastroenterologist at University Hospitals Coventry & Warwickshire. ‘By using this technology we can analyse stool samples and sniff out the chemicals that are produced by these microflora to better predict the risk of side effects.’

The success of the pilot study is expected to lead to a broader investigation into the possible uses of these technologies and could be significant in helping clinicians inform patients receiving pelvic radiotherapy, before treatment is started.

‘In essence, we will be able to predict those who are likely to develop severe gut related side effects by the pattern of gut fermentation that are altered as a result of radiotherapy,’ said Dr Arasaradnam in a statement. ‘This will enable future directed therapy in these high risk groups.’

Dr James Covington, from the Warwick School of Engineering added, ‘This technology offers considerable opportunities for the future. This shows just one application of being able to inform treatment by ‘sniffing’ patients. We foresee a time when such technology will become as routine a diagnostic test as checking blood pressure is today.’

The technology was first developed at Warwick in the early 1990s and has since been in continuous development.

In 2009, the same gas sensor was taken from the automotive world and used to research into quicker diagnosis for some gastrointestinal illnesses and metabolic diseases.