Device lights road to potential therapies for Alzheimer's

Researchers at Strathclyde University found that they could track the formation of protein clumps that are linked to Alzheimer’s disease using short pulses of light.

One of the key causes of Alzheimer’s is thought to be the aggregation of defective proteins that coalesce to form fibrils and plaques, subsequently contributing to neuro-degeneration and the symptoms of the disease.

The process is still poorly understood by scientists, but it is believed that the early stages of plaque formation — when protein monomers start to bind together — is a central part of the resulting cascade.

Unfortunately, current techniques are only sensitive enough to detect large plaques at the advanced stages of the disease.

In their latest research, the team found that intermediate protein aggregates naturally emitted a fluorescent signal when exposed to a certain wavelength of light that could then be detected using modified spectroscopy.

Project lead Prof Olaf Rolinski of Strathclyde explained that the main advantage of the system is that it is potentially non-invasive and doesn’t need contrast agent or chemical tags like many other medical-screening techniques.