Erupting ‘nano-volcanoes’ designed to deliver drugs

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Researchers from North Carolina State University have developed a method for creating so-called ‘nano-volcanoes’ that could be used for new drug-delivery technologies.

The researchers created the nano-volcanoes by placing spherical, transparent polymer nanoparticles directly onto the flat surface of a thin film. They then applied ultraviolet light through the transparent sphere, which scatters the light and creates a pattern on the thin film.

The thin film is made of a photoreactive material that undergoes a chemical change wherever it has been struck by the light. The researchers then submerged the thin film in a liquid solution that washed away the parts of the film that were exposed to light. The material that remains is shaped like a nanoscale volcano.

‘We can control the pattern of light by changing the diameter of the nanoparticle spheres, or by changing the wavelength – or colour – of the light that we shine through the spheres,’ said Xu Zhang, a doctoral student in mechanical and aerospace engineering at NC State and lead author of a paper describing the work. ‘That means we can control the shape and geometry of these structures, such as how big the cavity of the nano-volcano will be.’

According to NCSU, the researchers developed a highly accurate computer model that predicts the shape and dimensions of the nano-volcanoes based on the diameter of the nanoscale sphere and the wavelength of light.

Because these structures have precisely measured hollow cores, and precisely measured openings at the ‘mouth’ of the nano-volcanoes, they are good candidates for drug-delivery mechanisms.

The size of the core would allow users to control the amount of the drug a nano-volcano would store, while the size of the opening at the top of the nano-volcano could be used to regulate the drug’s release.

‘The materials used in this process are relatively inexpensive, and the process can be easily scaled up,’ said Dr. Chih-Hao Chang, an assistant professor of mechanical and aerospace engineering at NC State and co-author of the paper. ‘In addition, we can produce the nano-volcanoes in a uniformly patterned array, which may also be useful for controlling drug delivery.’

Chang’s team is now working to improve its understanding of the release rate from the nano-volcanoes, such as how quickly nanoparticles of different sizes will leave nano-volcanoes with different-sized mouths. ‘That’s essential information for drug-delivery applications,’ Chang said in a statement.

‘It’s exciting to take our understanding of how light scatters by particles and apply it to nanolithography in order to come up with something that could actually help people.’

The paper, Three-Dimensional Nanolithography Using Light Scattering from Colloidal Particles, was published online in ACS Nano.