Hidden toxicity

A physicist and a medical researcher at the

have received a grant of £100,000 from the Engineering and Physical Sciences Research Council to look at possible toxic damage from inhaled nanoparticles.

Nanoparticles in the size range 5-100 nm are used in applications as diverse as face creams, plastics, medical imaging, novel drug therapies and magnetic recording. Such particles are increasingly manufactured and released into the environment on industrial scales.

However, there is growing concern that the very same properties that make them so useful may also lead to enhanced toxicity if the particles are breathed in. The particles are so small that it is not clear how the body's normal defence mechanisms will cope with them.

By harnessing their combined expertise in physics and medicine, Dr. Paul Howes, Department of Physics & Astronomy, and Dr. Jonathan Grigg, Department of Infection, Immunity and Inflammation, will research possible toxic damage from inhaled nanoparticles.

Howes and Grigg will produce macrophages from human blood monocytes and expose them, in vitro, to an aerosol of metal nanoparticles, measuring any toxic damage to their DNA. Precise control over the size, chemical composition and dose of particles with enable them to determine whether there is a correlation between size and toxicity.