Lab on a chip looks set to aid the treatment of malaria

Spread by mosquitoes, malaria is caused by a parasite that infects human red-blood cells. Ma and his team designed a ‘lab-on-a-chip’ device to better understand the changes in red-blood cells caused by Plasmodium falciparum, the most common species of malaria parasites.

Ma explained in a statement that the device will help those conducting laboratory research or clinical trials evaluate the efficacy of different compounds in treating malaria, a disease that is increasingly resistant to drugs.

‘Our results show that it’s possible to precisely measure the stiffening of red-blood cells caused by the parasite at various stages of infection,’ said Ma, assistant professor in the UBC departments of mechanical engineering and urologic sciences, and senior research scientist at the Vancouver Prostate Center.

Normal human red-blood cells must squeeze through capillaries many times smaller than their own diameter in order to deliver oxygen to all tissues in the body. Red-blood cells infected with malaria gradually lose this capability, which disrupts blood flow, causing failure of vital organs and eventually death.