Manufacturing details released for tissue nanotransfection device

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A silicon device that changes skin tissue into blood vessels and nerve cells has advanced from prototype to standardised fabrication.  

The tissue nanotransfection device, developed at the Indiana University School of Medicine and reported in Nature Protocols, brings the device a step closer to be used for medical treatment.

The non-invasive nanochip device can reprogram tissue function by applying an electric spark to deliver specific genes in a fraction of a second. In laboratory studies, the device converted skin tissue into blood vessels to repair an injured leg. The technology is currently being used to reprogram tissue for different kinds of therapies, such as repairing brain damage caused by stroke or preventing and reversing nerve damage caused by diabetes.

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"This report on how to exactly produce these tissue nanotransfection chips will enable other researchers to participate in this new development in regenerative medicine," said lead author Chandan Sen, director of the Indiana Center for Regenerative Medicine and Engineering, associate vice president for research and Distinguished Professor at the IU School of Medicine.

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