’Positron emission tomography [PET] is a powerful tool for studying the molecular processes that occur in the brain,’ said Paul Vaska, head of PET physics at Brookhaven, who led the development of the portable scanner together with Brookhaven colleagues David Schlyer and Craig Woody.
But studying animals with PET has required general anaesthesia or other methods to immobilise the animals.
’Immobilisation and anaesthesia make it impossible to simultaneously study neurochemistry and the animals’ behaviour — the actions resulting from what goes on in the brain,’ Schlyer said.
’Our approach was to eliminate the need for restraint by developing a PET scanner that would move with the animal, thus opening up the possibility of directly correlating the imaging data with behavioural data acquired at the same time,’ he added.
The miniature, portable, doughnut-shaped PET scanner can be worn like a collar on a rat’s head for simultaneous studies of brain function and behaviour.
Weighing only 250g, the device — dubbed RatCAP, for Rat Conscious Animal PET — is counterbalanced by a system of springs and motion stabilisers to allow the animal significant freedom of movement.