The group at the University of Illinois at Urbana-Champaign has published its work in Proceedings of the National Academy of Science.
‘Biological actuation driven by cells is a fundamental need for any kind of biological machine you want to build,’ said study leader Rashid Bashir, Abel Bliss Professor and head of bioengineering at the U. of I. ‘We’re trying to integrate these principles of engineering with biology in a way that can be used to design and develop biological machines and systems for environmental and medical applications. Biology is tremendously powerful, and if we can somehow learn to harness its advantages for useful applications, it could bring about a lot of great things.’
Previously, the group demonstrated bio-bots that ‘walk’ on their own, powered by beating heart cells from rats. However, heart cells constantly contract, denying researchers control over the bot’s motion. This makes it difficult to use heart cells to engineer a bio-bot that can be turned on and off, sped up or slowed down.
The new bio-bots are reportedly powered by a strip of skeletal muscle cells that can be triggered by an electric pulse. This gives the researchers a simple way to control the bio-bots and opens the possibilities for other forward design principles, so engineers can customise bio-bots for specific applications.
‘Skeletal muscles cells are very attractive because you can pace them using external signals,’ Bashir said in a statement. ‘For example, you would use skeletal muscle when designing a device that you wanted to start functioning when it senses a chemical or when it received a certain signal. To us, it’s part of a design toolbox. We want to have different options that could be used by engineers to design these things.’
The design is inspired by the muscle-tendon-bone complex found in nature. There is a backbone of 3D printed hydrogel, strong enough to give the bio-bot structure but flexible enough to bend like a joint. Two posts serve to anchor a strip of muscle to the backbone, like tendons attach muscle to bone, but the posts also act as feet for the bio-bot.
A bot’s speed can be controlled by adjusting the frequency of the electric pulses. A higher frequency causes the muscle to contract faster, thereby speeding up the bio-bot’s progress.
‘It’s only natural that we would start from a bio-mimetic design principle, such as the native organisation of the musculoskeletal system, as a jumping-off point,’ said graduate student Caroline Cvetkovic, co-first author of the paper. ‘This work represents an important first step in the development and control of biological machines that can be stimulated, trained, or programmed to do work…this system could eventually evolve into a generation of biological machines that could aid in drug delivery, surgical robotics, ‘smart’ implants, or mobile environmental analysers.’
Next, the researchers will work to gain even greater control over the bio-bots’ motion, like integrating neurons so the bio-bots can be steered in different directions with light or chemical gradients. On the engineering side, they hope to design a hydrogel backbone that allows the bio-bot to move in different directions based on different signals.
‘The idea of doing forward engineering with these cell-based structures is very exciting,’ Bashir said. ‘Our goal is for these devices to be used as autonomous sensors. We want it to sense a specific chemical and move towards it, then release agents to neutralize the toxin, for example. Being in control of the actuation is a big step forward toward that goal.’
£22bn for CCUS and hydrogen in northern clusters
It would make more sense to move the east coast project from Teesside down to South Humberside where there is existing demand for hydrogen (Phillips...