Organ-on-a-Chip aims to push through drug approvals

Preclinical drug testing aims to exclude toxic effects and predetermine concentrations and administration routes before drug candidates can be tested in people. However, predicting the movement of medicines and their effects on the body cannot be done accurately enough in animal and standard in vitro studies.

"To solve this massive preclinical bottleneck problem, we need to become much more effective at setting the stage for drugs that are truly promising and rule out others that for various reasons are likely to fail in people," said Prof Donald Ingber, MD, PhD, founding director of Harvard University's Wyss Institute for Biologically Inspired Engineering, co-author of two new studies on the subject published in Nature Biomedical Engineering.

UK developed 3D organ on a chip could lead to new disease treatments

Biosensor lights up organ-on-a-chip technology