Stick sensor detects cancer in urine

When cancer cells proliferate in the body, the change in metabolism leads to different metabolites being secreted into urine. Led by Dr Ho Sang Jung, the research team developed a surface-enhanced Raman scattering sensor that amplifies the optical signal of metabolites in urine more than 1 billion times by forming a coral-shaped plasmonic nanomaterial on porous paper. When urine is dropped into the sensor and light is irradiated, cancer metabolite signals are amplified on the sensor surface, making it possible to diagnose cancer. 

In testing, the KIMS team used an AI-based analysis method on the acquired spectral signal. They succeeded in detecting up to 99 per cent of prostate cancer and pancreatic cancer patients. The work is published in Biosensors and Bioelectronics.

“In the case of cancers where the diagnosis method is not well known, such as pancreatic cancer, it is difficult to detect and the survival rate after initial diagnosis is low,” said Ho Sang Jung.