Protein research

A two-year, $200,000 grant from the New York State Office of Science, Technology and Academic Research (NYSTAR) will help a

mechanical engineer design smaller, faster and cheaper devices for processing and producing proteins.

Brian Kirby, Cornell assistant professor of mechanical engineering, won NYSTAR's 2004 James D. Watson Investigator Award, which is part of the $225 million Generating Employment Through New York State Science (Gen*NY*sis) program.

The biotechnology and pharmaceutical industries are interested in cheaper and faster ways to produce and process protein pharmaceuticals, such as insulin, Kirby says. He seeks to use mechanical engineering to solve problems associated with a widely used technique, called high-performance liquid chromatography (HPLC), for separating and identifying proteins.

"Any time anyone does an experiment to understand how proteins are expressed in an organism, they use HPLC to quantify them," Kirby explains.

The machines that currently perform HPLC are about twice the size of a desktop computer. Kirby plans to make hand-held devices packaged in a 4-inch cube that can separate and identify proteins. The miniaturised device should be faster, cheaper and better suited to work with smaller volumes of proteins.