Engineers have developed a smartphone case and app that could make it easier for diabetics to record and track their blood glucose readings.
The advance by engineers at the University of California San Diego integrates blood glucose sensing into a smartphone and eliminates the need for patients to carry a separate device
"An added benefit is the ability to autonomously store, process and send blood glucose readings from the phone to a care provider or cloud service.” said Patrick Mercier, a professor of electrical and computer engineering at UC San Diego.
Dubbed GPhone, the device is a new proof-of-concept portable glucose sensing system developed by Patrick Mercier, nanoengineering professor Joseph Wang, and their colleagues at the UC San Diego Jacobs School of Engineering. Wang and Mercier are the director and co-director, respectively, of the Center for Wearable Sensors at UC San Diego. Their team published the work in Biosensors and Bioelectronics.
GPhone has two main parts: a 3D printed case that fits over a smartphone and has a permanent, reusable sensor on one corner; and small, single use, enzyme-packed pellets that magnetically attach to the sensor. The pellets are housed inside a 3D printed stylus attached to the side of the smartphone case.
To run a test, the user would first take the stylus and dispense a pellet onto the sensor to activate it. The user would then drop a blood sample on top. The sensor measures the blood glucose concentration, then wirelessly transmits the data via Bluetooth to a custom-designed Android app that displays the numbers on the smartphone screen. The test takes about 20 seconds.
Afterwards, the pellet is discarded, deactivating the sensor until the next test. The stylus is said to hold enough pellets for 30 tests before it needs to be refilled. A printed circuit board enables the whole system to run off a smartphone battery.
The pellets contain glucose oxidase, an enzyme that reacts with glucose. This reaction generates an electrical signal that can be measured by the sensor's electrodes. The greater the signal, the higher the glucose concentration. The team tested the system on different solutions of known glucose concentrations and the results were accurate throughout multiple tests.
In previous glucose sensors developed by the team, the enzymes were permanently built in on top of the electrodes, but they wore out after several uses. The sensor would no longer work and had to be completely replaced. Keeping the enzymes in separate pellets resolved this issue.
"This system is versatile and can be easily modified to detect other substances for use in healthcare, environmental and defence applications," Wang said in a statement. The system stores a considerable amount of data so that users can track their readings over long time periods. However, there is a trade-off in price. While the reusable glucose sensor and 3D printed parts are inexpensive, refill pellets may be slightly more costly than test strips in today's glucose monitoring kits.
The team envisions integrating glucose sensing directly into a smartphone rather than a case. The work is currently at the proof-of-concept stage and next steps will include testing on actual blood samples and minimising sample volumes as the current prototype uses at least a dozen drops of sample per test.
The researchers aim to cut that down to an amount that's normally extracted from a finger prick. They also plan to include a function in the app that sends phone alerts reminding users to check their blood sugar.
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