Biomaterial used for repair mimics native human tissue

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A new biomaterial designed for repairing damaged human tissue developed at the University of California, San Diego, more closely mimics the properties of native human tissue.

The new biomaterial was created using a new biofabrication technique that Shaochen Chen, a professor in the Department of NanoEngineering at UC San Diego’s Jacobs School of Engineering, is developing under a four-year, $1.5m (£919,000) grant from the US National Institutes of Health.

It uses precisely controlled mirrors and a computer projection system to shine light on a solution of cells and polymers to build three-dimensional scaffolds with well-defined patterns of any shape.

Shape turned out to be essential to the new material’s mechanical property. While most engineered tissue is layered in scaffolds that take the shape of circular or square holes, Chen’s team created two new shapes called ’re-entrant honeycomb’ and ’cut missing rib’.

Both shapes exhibit the property of negative Poisson’s ratio (not becoming thinner in cross section when stretched) and maintain this property whether the tissue patch has one or multiple layers. One layer is double the thickness of a human hair and the number of layers used in a tissue patch depends on the thickness of the native tissue that doctors are trying to repair.

The next phase of research will involve working with the Department of Bioengineering at the Jacobs School of Engineering to make tissue grafts to repair damaged blood vessels.