Piezoelectric biomaterial could help treat CNS injuries

Made of cellulose and potassium sodium niobate (KNN) piezo-ceramic particles, the biomaterial is created using a process called directional freeze casting, where the structure is optimised to encourage the growth of cells in a specific direction. The composite is also porous, with space for new cells spaces to grow into, mimicking the three-dimensional network in the body. 

Ceramic microparticles have piezoelectric properties, meaning they create electrical charge when placed under stress or through body movement. This provides stem cells with the stimulation they need to grow, potentially creating new treatments for patients with brain or spinal cord injuries, as well as diseases such as Alzheimer’s and Parkinson's. The research is published in Cell Reports Physical Science.  

“This is a ground breaking biomaterial, which has the potential to redefine the prospects of recovery from central nervous system injuries or neurodegenerative diseases,” said Dr Hamideh Khanbareh, senior lecturer at Bath’s Department of Mechanical Engineering and a member of the Centre for Integrated Materials, Processes & Structures (IMPS).