Characterization of Wrinkle Formation in a Polymeric Drug Coating by Atomic Force Microscope and Grazing Incidence Small-Angle X-Ray Scattering

Surface structure of polymeric drug delivery coating plays an important role on controlled drug release. To get a full picture of the qualitative and quantitative properties, two complementary techniques are used namely, atomic force microscopy (AFM) and grazing incidence small angle x-ray scattering (GISAXS). Due to unique integrated measurement workflow of the Tosca 400 AFM, the surface texture and grain size are characterized with unprecedented efficiency, while GISAXS gives a deeper insight into structural changes upon a larger area of the studied thin films.

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