Peristaltic pump for single-use downstream bioprocessing

1 min read

Quantum peristaltic pump

Watson-Marlow Fluid Technology Group has unveiled its Quantum peristaltic pump with patented ReNu single-use (SU) Technology cartridge. Quantum has been designed to set a new standard for high-pressure feed pumps in SU tangential flow filtration (TFF), virus filtration (VF) and high-performance liquid chromatography (HPLC). Quantum enables higher downstream process yields throughout the pressure range, delivering virtually pulse free linear flow, lowest shear and easy validation aligned with BPOG guidelines.

Quantum delivers higher accuracy with flow linearity independent of back-pressure, removing the need for flow meters and load cells. Flow linearity is achieved across the 3 bar SU processing pressure range up to 20 litre/min, with trace pulsation of only ±0.12 bar that is far lower than other pumps.  This virtually pulse-free performance enables constant pressure, thus maximising process efficiency and yield.

Another major benefit is ultra-low shear, half that of diaphragm pumps, a factor that increases product viability to help maximise process yield. In addition, an integrated 4,000:1 speed control ratio allows users to sustain constant transmembrane pressure in micro and ultrafiltration. Being limited to a 200:1 control ratio in HPLC gradient work is now a problem of the past. Uniquely, the user interface is located at the front of the pump, enabling visual confirmation of operating state and easy access to pump controls even when skid mounted.

At the heart of the Quantum pump is the patented ReNu SU Technology cartridge, which is simple to install, enabling its aseptic fluid paths to be positioned quickly and accurately ready for use.

The synergy between peristaltic pumps and single-use pump systems cannot be overstated. The ReNu SU Technology cartridge slides effortlessly into position allowing for a change of fluid path in minutes while eliminating alignment errors.

Quantum’s ReNu SU Technology cartridge offers validation and extractable data in line with BPOG/BPSA/USP/ISO guidelines. Suitable for gamma irradiation up to 50kGy, the ReNu SU Technology cartridge is manufactured in an ISO Class 7 cleanroom, with all contact material tested for biocompatibility and BPOG derived extractable studies. Available as a cartridge or as a component within a BioPure puresu single-use fluid path assembly, Quantum’s ReNu SU Technology cartridge delivers considerable reduction in the cost and time of pump and process validation.