Researchers from the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences have discovered a new mechanism for using light to activate drug-delivering nanoparticles and other targeted therapeutic substances inside the body.
This discovery represents a major innovation, said Adah Almutairi, PhD, associate professor and director of the joint UC San Diego-KACST Center of Excellence in Nanomedicine. Up to now, she said, only a handful of strategies using light-triggered release from nanoparticles have been reported.
The mechanism, developed in collaboration with materials scientists, engineers and neurobiologists and described in ACS Nano, employs near-infrared (NIR) light from a low-power laser to heat pockets of water trapped within non-photo-responsive polymeric nanoparticles infused with drugs.
The water pockets absorb the light energy as heat, which softens the encapsulating polymer and allows the drug to be released into the surrounding tissue. The process can be repeated multiple times, with precise control of the amount and dispersal of the drug.
‘A key advantage of this mechanism is that it should be compatible with almost any polymer, even those that are commercially available,’ said Mathieu Viger, a post-doctoral fellow in Almutairi’s laboratory and co-lead author of the study. ‘We’ve observed trapping of water within particles composed of all the biodegradable polymers we’ve so far tested.’
According to UC San Diego, the combined use of hydrated polymers and near-infrared light appears to resolve a host of technological and health barriers that have hindered previous, similar approaches.
Earlier efforts to use NIR-triggered release have not been widely exploited because they required special designer polymers, expensive high-powered lasers and/or the co-encapsulation of inorganic particles whose safety in the body remains questionable.
The new method described by Almutairi and colleagues in the departments of Mechanical and Aerospace Engineering, Neuroscience, and Chemistry and Biochemistry at UC San Diego uses NIR at a vibrational wavelength cued to excite water molecules, which absorb the optical energy and convert it to heat. NIR is capable of penetrating biological tissues to greater depths than visible or ultraviolet light.
In a statement, Almutairi said an obvious use of the method is light-triggered drug delivery, but with more research, she anticipates the new method could provide a variety of industrial, medical and scientific applications, including ‘any technological application requiring that chemistry be controlled in time and in space, such as in catalysis or self-repairing materials or light-activated sunscreens or pesticide dosing.’