Psychiatric conditions could be treated with targeted transcranial ultrasound stimulation

Research by neuroscientists at Plymouth University explored the impacts of the emerging technique, which is detailed in Nature Communications.

Ultrasound examinations involve diffuse broad beams of ultrasound being used to create images while leaving the target tissue unaffected. Focusing the beams through TUS can increase the pressure in the target region and change the way neurons communicate.

The research team said a study involving 24 healthy adults showed that TUS can induce significant changes in GABA (gamma-aminobutyric acid) concentration within the brain’s posterior cingulate cortex in the hour following ultrasound treatment.

The study also showed that in the hour following the TUS treatment, the way the posterior cingulate cortex communicates with the rest of the brain was also profoundly altered.

However, the changes were not consistent across all areas, with GABA levels not being altered in the anterior cingulate cortex, another cortical area equally related to psychiatric conditions but underlying different cognitive functions, particularly related to decision making, learning and attention regulation.

In a statement, Dr Siti Yaakub, a Postdoctoral Research Fellow at the University and the study’s lead author, said: “It was very interesting to see that when we targeted two different brain regions, it resulted in different changes in GABA concentration. This suggests that some TUS protocols work well for certain parts of the brain and not so well for others. Or maybe there is another mechanism at play, like the fact that the region needs to be in a certain state for the intervention to work, and that is something we clearly need to explore.”

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The research team – including experts from the University Hospitals Plymouth NHS Trust, University College London, Oxford University and Radboud University Nijmegen in the Netherlands – said the study represents an important first step in the generation of clinical applications that could use ultrasound to treat mental health disorders.

They said the study provides evidence that TUS works in humans and that changes in the brain are reversible, although more work is required before it can be applied in a clinical setting.

They are exploring whether TUS can be used to change the dopaminergic system, which could alter how people make decisions, learn, and are motivated to engage in certain behaviours relevant to addiction.

Senior author Dr Elsa Fouragnan, Associate Professor of Neuroscience at Plymouth University and a UK Research and Innovation Future Leaders Fellow, said: “One of the long-term aspirations of neuroscientists is to find ways to change activity in only certain parts of the brain while leaving the rest unchanged. If you are taking medication for depression, for example, the drug will impact the entire brain and clinicians have very limited control over where the drug goes and what it does.

“We already know that specific regions of the brain - and some of their connections - are dysfunctional in certain conditions but other regions can work perfectly well. This study provides us with the genuine potential to think about using ultrasound for more targeted interventions in people with a range of mental health conditions.”

The study was carried out at Plymouth University’s Brain Research and Imaging Centre, a research facility opened in 2022 to help better understand brain activity and human behaviour.